Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles
نویسندگان
چکیده
منابع مشابه
Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles
The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogi...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2013
ISSN: 1178-2013
DOI: 10.2147/ijn.s54050